Protein Details: ATP-sensitive inward rectifier potassium channel 10

Protein ID

ICDB_Pro_0696

Protein Name

ATP-sensitive inward rectifier potassium channel 10

Gene Name

KCNJ10

Organism

Homo sapiens (Human)

Length

379 amino acids

AlphaFoldDB

AF-P78508-F1-model_v4.pdb

Function

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney;together with KCNJ16;mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules

Sequence

MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

210..217

Disease

Seizures;Sensorineural Deafness;Ataxia;Impaired Intellectual Development;And Electrolyte Imbalance and Deafness;Autosomal Recessive 4;With Enlarged Vestibular Aqueduct

Location

Expressed in kidney (at protein level).

DOI ID

10.1074/jbc.272.1.586; 10.1016/s0898-6568(99)00059-5; 10.1038/nature04727; 10.1101/gr.2596504; 10.1016/j.febslet.2014.02.024; 10.1056/nejmoa0810276; 10.1073/pnas.0901749106; 10.1111/j.1528-1167.2012.03516.x; 10.1002/humu.23335

RefSeq

NP_002232.2